PKUMDL WQ 2201
Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
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包装价格促销价数量
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5mg￥1112.00890.00- +
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25mg￥4037.003230.00- +
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- 货号: ajcx27698
- CAS: 592474-91-4
- 别名:
- 分子式: C15H14ClN3O3S
- 分子量: 351.81
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID:28042046
