安捷凯在线客服
- 客服:
- 电话: 13061953619
- 微信:
Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
Negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID:28042046
动态评分
0.0