L-叠氮高丙氨酸盐酸盐是一种基于烷基链的 PROTAC 接头，可用于 PROTAC 的合成。
Unnatural amino acid. Incorporated into proteins during de novo protein synthesis, with no effect on protein degradation. Requires methionine-free medium for efficient incorporation. Substrate for wild-type methionyl-tRNA synthetase (MetRS) in vivo. Can be used in BONCAT (bio-orthogonal non-canonical amino acid tagging) for the identification of newly synthesized proteins.
Dieterich et al (2006) Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proc.Natl.Acad.Sci.U.S.A. 103 9482 PMID:16769897 |Lang & Chin et al (2014) Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins. Chem.Rev. 114 4764 PMID:24655057 |Wang et al (2017) Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling. Nat.Protoc. 12 279 PMID:28079880
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