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- Ligand for Target Protein for PROTAC
- Thalidomide 4'-ether-alkylC6-amine
Thalidomide 4'-ether-alkylC6-amine
Thalidomide 4'-ether-alkylC6-amine 是一种合成的 E3 连接酶配体-接头偶联物，用于 PROTAC dTAG-13，FKBP12F36V 和 BET 的降解剂。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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25mg￥2712.002170.00- +
- 货号: ajcx27734
- CAS: 2245697-88-3
- 别名:
- 分子式: C19H23N3O5.HCl
- 分子量: 409.86
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: 4°C, protect from light
- 库存: 现货
Background
Functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a C6 alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D. This product has been recently renamed. The previous name for this product was Thalidomide - linker 4 PROTAC? is a registered trademark of Arvinas Operations, Inc., and is used under license.
Nabet et al (2018) The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 14 431 PMID:29581585 |Erb et al (2017) Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 543 270 PMID:28241139
