Pomalidomide 4'-PEG2-amine 是一种合成的 E3 连接酶配体-接头偶联物，它包含基于 Thalidomide 的 cereblon 配体和用于 PROTAC 技术的 2 单元 PEG 接头。
Functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG2 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 1 PROTAC? is a registered trademark of Arvinas Operations, Inc., and is used under license.
Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID:28418626
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