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- Ribosomal S6 Kinase (RSK)
- ELA-11 (human)
ELA-11 (human)
ELA-11 (human) 是一种肽，是人 apelin 受体的完全激动剂，pKi 为 7.85。
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1mg￥3525.002820.00- +
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- 货号: ajcx27776
- CAS: 1784687-32-6
- 别名:
- 分子式: C58H90N16O13S2
- 分子量: 1283.57
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32 . Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
Yang et al (2017) Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation 135 1160 PMID:28137936 |Murza et al (2016) Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 59 2962 PMID:26986036
