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  • PHPS1 sodium salt
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PHPS1 sodium salt

A selective SHP-2 inhibitor

原价
¥3200-12225
价格
2560-9780
PHPS1 sodium salt的二维码

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  • 库存: 现货
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  • 货号: ajcx27810
  • CAS: N/A
  • 别名:
  • 分子式: C21H14N5O6SNa
  • 分子量: 487.42
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Shp2 (PTPN11) inhibitor (IC50 = 2.1 μM). Inhibits hepatocyte growth factor-stimulated epithelial cell scattering and branching morphogenesis in vitro. Increases myelin basic protein (MBP) levels in zebrafish embryo spinal cord. Also ameliorates bleomycin-induced pulmonary and dermal fibrosis in vivo.



Hellmuth et al (2008) Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc.Natl.Acad.Sci.U.S.A 105 7275 PMID:18480264 |Ahrendsen et al (2018) The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination. J.Neurosci. 38 787 PMID:29217681 |Zehender et al (2018) The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat.Commun. 9 3259 PMID:30108215

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