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- ZAP 180013
ZAP 180013
ZAP 180013 是一种 zeta 链相关蛋白激酶 70 (ZAP-70) 抑制剂，IC50 为 1.8 μM。
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包装价格促销价数量
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10mg￥1512.001210.00- +
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50mg￥5187.004150.00- +
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- 货号: ajcx27828
- CAS: 873080-25-2
- 别名:
- 分子式: C19H17Cl2N3O4S
- 分子量: 454.32
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Zeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC50 = 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.
Visperas et al (2017) Identification of inhibitors of the association of ZAP-70 with the T-cell receptor by high-throughput screen. SLAS.Discov. 22 324 PMID:27932698
