Fluorescent retinoic acid analog (retinoid all-trans-retinoic acid; ATRA) (Kd = 42 nM at cellular retinoid binding protein II (CRABPII))
Fluorescent retinoic acid analog (retinoid all-trans-retinoic acid; ATRA) (Kd = 42 nM at cellular retinoid binding protein II (CRABPII)). Solvochromatic probe: fluorescent λex, λem, and quantum yield affected by solvent type. Activates same genes as endogenous retinoic acid in human keratinocyte cells (HaCaT) when incubated for 72 h at 1 μM. Also elicits cellular responses consistent with those of retinoic acid. Excitation λ = 351, 350, 382 and 378 nm in DMSO, EtOH, DCM and Toluene, respectively; emission λ = 442, 461, 572 and 447 nm in DMSO, EtOH, DCM and Toluene, respectively. Quantum yield = 19.3, 1.14, 71.45, 80.21 % in DMSO, EtOH, DCM and Toluene, respectively
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