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  • dTAGV-1
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dTAGV-1

Degrader targeting mutant FKBP12F36V fusion proteins

原价
¥8100-8100
价格
6480-6480
dTAGV-1的二维码

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  • 货号: ajcx28184
  • CAS: N/A
  • 别名:
  • 分子式: C68H90N6O14S CF3CO2H
  • 分子量: 1361.58
  • 纯度: >98%
  • 溶解度: DMSO|136.16|100|
  • 储存: Store at -20°C
  • 库存: 现货

Background

Degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand. Induces potent and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. Selectively degrades FKBP12F36V-EWS/FLI fusion proteins and inhibits cell proliferation in FKBP12F36V-EWS/FLI-expressing Ewing sarcoma cells. Hydrochloride salt? available; suitable for in vivo use. Negative control dTAGV-1-NEG also available. FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems. Email TPD@bio-techne.com to enquire. Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.



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