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- (Rac)-Tavapadon
(Rac)-Tavapadon
(Rac)-Tavapadon((Rac)-PF-06649751;(Rac)-CVL-751)是有效的，选择性非儿茶酚多巴胺D1受体(dopamineD1receptor)激动剂。(Rac)-Tavapadon在GS激活试验中显示出强大的完全激动作用，在β-arrestin2募集试验中显示出部分激动作用(GS-cAMP,EC50=0.8nM;β-arrestin2,EC50=68nM)。(Rac)-Tavapadon具有抗帕金森病活性。
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包装价格促销价数量
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5mg￥1625.001300.00- +
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10mg￥2725.002180.00- +
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50mg￥7337.005870.00- +
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100mg￥11337.009070.00- +
- 货号: ajcx29022
- CAS: 1643462-64-9
- 别名: (Rac)-PF-06649751; (Rac)-CVL-751
- 分子式: C19H16F3N3O3
- 分子量: 391.34
- 纯度: ＞98%
- 溶解度: DMSO: 41.67 mg/mL (106.48 mM); Water: < 0.1 mg/mL (insoluble)
- 储存: Store at -20°C
- 库存: 现货
Background
(Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM). (Rac)-Tavapadon has antiparkinsonian activity[1].
(Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751; compound 32) has EMAXs of 118% and 30% in the GS activation assay and the β-arrestin2 recruitment assay[1].
[1]. Michael L Martini, et al. Designing Functionally Selective Noncatechol Dopamine D 1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. ACS Chem Neurosci. 2019 Sep 18;10(9):4160-4182.
