- 客服:
- 电话: 13061953619
- 微信:
1,3-二噻烷2位的亚甲基氢具有较高的酸度(pKa31.1),在烷基锂等强碱作用下可生成烷基阴离子物种。由于硫缩醛通过脱保护转化为羰基,1,3-二噻烷可用作酰基阴离子等价物(酰基极性改变)。也就是说,酮醛可以通过使亲核试剂如卤代烷反应然后将产物水解来获得。它也可以通过脱硫反应转化为烷烃。
1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon[1]. 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward S. typhimurium TA98 and TA100[2].
[1]. Lee H, et al. Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test. Mutat Res. 1994 Jun;321(4):213-8. [2]. Martinez RA, et al. Synthesis of isotopically labeled 1,3-dithiane. J Labelled Comp Radiopharm. 2014 May 15;57(5):338-41.
动态评分
0.0