2-Methylthioadenosine diphosphate trisodium

An agonist of P2Y receptors

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5mg

￥5612.00

4490.00

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货号: ajcx29048
CAS: 475193-31-8
别名: 2-甲基硫代二磷酸腺苷,2-Methylthio-ADP trisodium
分子式: C11H14N5Na3O10P2S
分子量: 539.24
纯度: >98%
溶解度: PBS (pH 7.2): 10 mg/mL,Water: soluble
储存: Store at -20°C
库存: 现货

Background

2-Methylthioadenosine diphosphate (2-MeSADP) is an agonist of purinergic P2Y receptors with EC₅₀s of 5.13 and 0.89 nM for human recombinant P2Y₁ and P2Y₁₂ receptors, respectively.¹ It also acts as an agonist at rat P2Y₁ and P2Y₁₂ and mouse P2Y₁₃ receptors (EC₅₀s = 0.58, 0.89, and 6.2 nM, respectively).^1,2 It induces platelet aggregation and inhibits cyclic AMP accumulation in platelet-rich plasma stimulated by prostaglandin E₁ more potently than ADP .³

1.Sak, K., and Webb, T.E.A retrospective of recombinant P2Y receptor subtypes and their pharmacologyArch. Biochem. Biophys.397(1)131-136(2002) 2.Zhang, F.L., Luo, L., Gustafson, E., et al.P2Y13: Identification and characterization of a novel Gαi-coupled ADP receptor from human and mouseJ. Pharmacol. Exp. Ther.301(2)705-713(2002) 3.Macfarlane, D.E., Srovastava, P.C., and Mills, D.C.2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood plateletsJ. Clin. Invest.71(3)420-428(1983)