3,5-Difluoro-L-tyrosine是酪氨酸的一种功能性，耐酪氨酸酶的模拟物，可用于分析蛋白质酪氨酸磷酸酶(PTP)的底物特异性。
3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs)[1].
3,5-Difluoro-L-tyrosine (F2Y) is a fluorinated tyrosine analog. 3,5-Difluoro-L-tyrosine is compatible with every aspect of library synthesis, screening, and sequence identification. 3,5-Difluoro-L-tyrosine is a good functional mimic of tyrosine, in terms of binding to the active site of PTPs[1].
[1]. Bhaskar Gopishetty, et al. Synthesis of 3,5-difluorotyrosine-containing peptides: application in substrate profiling of protein tyrosine phosphatases. Org Lett. 2008 Oct 16;10(20):4605-8.
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