- 首页
- DNA/RNA Synthesis
- 3'-Deoxyuridine-5'-triphosphate
3'-Deoxyuridine-5'-triphosphate
3'-Deoxyuridine-5'-triphosphate(3'-dUTP)是一种核苷酸类似物，可抑制DNA依赖性RNA聚合酶I和II(RNApolymerasesI和II)，强烈并竞争性地抑制UTP掺入到RNA中，Ki值为2.0μM。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥23512.0018810.00- +
- 货号: ajcx29062
- CAS: 69199-40-2
- 别名: 3'-dUTP
- 分子式: C9H15N2O14P3
- 分子量: 468.14
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1].
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-triphosphate will be useful in studies at the molecular level on the relationship of template and substrate in RNA synthesis with chromatin, isolated nuclei or permeable cells, because it does not have any effect on poly (rA) synthesis[1].
[1]. M Saneyoshi, et al. Inhibitory Effects of 3'deoxycytidine 5'-triphosphate and 3'-deoxyuridine 5'-triphosphate on DNA-dependent RNA Polymerases I and II Purified From Dictyostelium Discoideum Cells. Nucleic Acids Res. 1981 Jul 10;9(13):3129-38.
