Amphotericin B methyl ester
A polyene antiviral and antifungal agent
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包装价格促销价数量
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50mg￥4962.003970.00- +
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100mg￥7875.006300.00- +
- 货号: ajcx29110
- CAS: 36148-89-7
- 别名: 两性霉素B甲酯90%
- 分子式: C48H75NO17
- 分子量: 938.11
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Amphotericin B methyl ester is a polyene antiviral and antifungal agent and a derivative of amphotericin B .1,2 It impairs viral particle production, as well as viral entry and infectivity, in HIV-1-infected TZM-bl cells when used at a concentration of 10 ?M.1 Amphotericin B methyl ester also inhibits replication of HIV-1 clinical isolates from a variety of clades in infected human peripheral blood mononuclear cells (PBMCs; IC50s = 0.5-5.5 ?M). It is active against S. cerevisiae (MIC = 0.25 ?g/ml) and reduces mortality in a mouse model of C. albicans infection when administered at doses of 1 and 10 mg/kg.2
1.Waheed, A.A., Ablan, S.D., Mankowski, M.K., et al.Inhibition of HIV-1 replication by amphotericin B methyl ester: Selection for resistant variantsJ. Biol. Chem.281(39)28699-28711(2006)
