Anti-SARS-CoV-2 Spike mAb (CR3022)

Anti-SARS-CoV-2 Spike mAb (CR3022) 是一种 CHO 细胞来源的、人源的单克隆抗体 IgG1，与SARS-CoV/SARS-CoV-2 Spike蛋白 (S1) 结合。

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货号: ajcx29126
CAS: N/A
别名: SARS-CR3022; SARS-CoV-2 Antibody-CR3022
分子式:
分子量:
纯度: >98%
溶解度:
储存: Store at -20°C
库存: 现货

Background

Anti-SARS-CoV-2 Spike mAb (CR3022) is a a CHO cell derived human monoclonal IgG1 antibody. It binds to both S1 domain of SARS-CoV/SARS-CoV-2 Spike protein[1][2].

CR3022 recognizes a cryptic epitope that is only accessible when S protein is in "open" conformations[1]. CR3022 binds more tightly to SARS-CoV because its epitope contains a glycan not present in SARS-CoV-2[2].

[1]. Yanling Wu, et al. Identification of Human Single-Domain Antibodies Against SARS-CoV-2. Cell Host Microbe. 2020 Jun 10;27(6):891-898.e5. [2]. Meng Yuan, et al. A Highly Conserved Cryptic Epitope in the Receptor Binding Domains of SARS-CoV-2 and SARS-CoV. Science. 2020 May 8;368(6491):630-633.