Azido-PEG2-C2-amine
Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) 是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。Azido-PEG2-C2-amine 也是一种不可降解 (non-cleavable) 的含 2 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。
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包装价格促销价数量
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250mg￥700.00560.00- +
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500mg￥925.00740.00- +
- 货号: ajcx29150
- CAS: 166388-57-4
- 别名: 2-[2-(2-叠氮乙氧基)乙氧基]乙胺,N3-PEG2-CH2CH2NH2
- 分子式: C6H14N4O2
- 分子量: 174.2
- 纯度: ＞98%
- 溶解度:
- 储存: -20°C, protect from light
- 库存: 现货
Background
Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. [2]. Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1.
