- 首页
- Angiotensin-converting Enzyme (ACE)
- Azido-PEG3-Val-Cit-PAB-PNP
Azido-PEG3-Val-Cit-PAB-PNP
Azido-PEG3-Val-Cit-PAB-PNP 是一种可降解 (cleavable) 的含 3 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Azido-PEG3-Val-Cit-PAB-PNP 还是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
50mg￥19237.0015390.00- +
-
100mg￥32587.0026070.00- +
- 货号: ajcx29154
- CAS: 2055047-18-0
- 别名:
- 分子式: C34H47N9O12
- 分子量: 773.79
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
