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A heterobifunctional PEGylated linker
Azido-dPEG7-amine is a heterobifunctional PEGylated linker.1 It contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions. Azido-dPEG7-amine has been used as a linker in the synthesis of bivalent mammalian target of rapamycin (mTOR) inhibitors.2
1.Goswami, L.N., Houston, Z.H., Sarma, S.J., et al.Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug deliveryOrg. Biomol. Chem.11(7)116-1126(2012) 2.Rodrik-Outmezguine, V.S., Okaniwa, M., Yao, Z., et al.Overcoming mTOR resistance mutations with a new-generation mTOR inhibitorNature534(7606)272-276(2016)
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