Deoxyelephantopin

Deoxyelephantopin是一种来自Elephantopusscaber的，具有生物活性的天然倍半萜烯内酯。可广泛用于癌症方面的研究。Deoxyelephantopin抑制NF-κB，MAPK，PI3K/Akt和β-catenin信号传导。

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1mg

￥1025.00

820.00

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5mg

￥2537.00

2030.00

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Background

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling[1].

Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively[1].Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells[1].

[1]. Farha Arakkaveettil Kabeer, et al. Molecular Mechanisms of Anticancer Activity of Deoxyelephantopin in Cancer Cells. Integr Med Res. 2017 Jun;6(2):190-206.