现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Dermaseptin TFA
Dermaseptin TFA的可视化放大

Dermaseptin TFA

Dermaseptin TFA 是从青蛙皮肤中分离出来的一种肽,在微摩尔浓度下表现出对细菌、真菌和原生动物强有力的抗菌 (antimicrobial) 活性。

原价
¥2175-9175
价格
1740-7340
Dermaseptin TFA的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx29276
  • CAS: N/A
  • 别名:
  • 分子式: C154H258N43F3O46S2
  • 分子量: 3569.12
  • 纯度: >98%
  • 溶解度:
  • 储存: -20°C, protect from light
  • 库存: 现货

Background

Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration[1].


Dermaseptin TFA is a water-soluble, thermostable, and nonhemolytic peptide endowed with highly potent antimicrobial activity against pathogenic fungi at micromolar concentration. Circular dichroism spectra of Dermaseptin TFA in hydrophobic media indicated 80% alpha-helical conformation, and predictions of secondary structure suggested that Dermaseptin TFA can be configured as an amphiphatic alpha-helix spanning over residues 1-27, a structure that perturbs membrane functions regulating water flux[1]. Dermaseptin TFA exerts a lytic action upon bacteria, protozoa, yeasts, and filamentous fungi at micromolar concentrations. Molecular elements responsible for the exceptional antimicrobial potency of Dermaseptin TFA are to be traced to the NH2-terminal alpha-helical amphipathic segment spanning residues 1-18 of the molecule[1].Dermaseptin TFA (5-100 μg/ml; 48 hours) inhibits by 100% the proliferation of most microorganisms tested, including Gram-positive or Gram-negative bacteria, parasites, yeasts, and filamentous fungi, at micromolar concentrations[2]. Dermaseptin TFA (5-100 μg/ml; 48 hours) does not inhibit the proliferation of human KJ3 cells after a 48 h incubation, and Dermaseptin TFA treatment for 1 h does not permeate guinea pig lymphocytes up to the highest concentration assayed (200 μg/ml). Hemolysis of rabbit erythrocytes occurrs after 1 h of treatment at doses above 200 μg/ml, with 50% hemolysis at 350 μg/ml[2]. Dermaseptin TFA has antimicrobial activities and is against Aeromonas cauiae, Pseudomonas aeroginusa, Escherichia coli, Enterococcus faecalis, L. mezicana (NFα strain) and Microsporum canis (IP1194) with MIC values of 50 μg/ml; 100 μg/ml; 25 μg/ml; 15 μg/ml; and 50 μg/ml, respectively[2].


[1]. Mor A, et al. Isolation, amino acid sequence, and synthesis of Dermaseptin TFA, a novel antimicrobial peptide of amphibian skin. Biochemistry. 1991 Sep 10;30(36):8824-30. [2]. Mor A, et al. The NH2-terminal alpha-helical domain 1-18 of Dermaseptin TFA is responsible for antimicrobial activity. J Biol Chem. 1994 Jan 21;269(3):1934-9.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服