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- ALK (Anaplastic lymphoma kinase)
- Lipoxamycin hemisulfate
Lipoxamycin hemisulfate
Lipoxamycin hemisulfate 是一种抗真菌抗生素，也是一种有效的丝氨酸棕榈酰转移酶 (serine palmitoyltransferase) 抑制剂，IC50 为 21 nM。
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包装价格促销价数量
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5mg￥8100.006480.00- +
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10mg￥13887.0011110.00- +
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25mg￥26712.0021370.00- +
- 货号: ajcx29464
- CAS: 11075-87-9
- 别名:
- 分子式: C19H36N2O5.1/2H2O4S
- 分子量: 421.54
- 纯度: ＞98%
- 溶解度: DMSO: 40 mg/mL (94.89 mM; ultrasonic and warming and heat to 60°C)
- 储存: Store at -20°C
- 库存: 现货
Background
Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].
Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays[1].Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme[1].
Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells[1].
[1]. S M Mandala, et al. Inhibition of Serine Palmitoyl-Transferase Activity by Lipoxamycin. J Antibiot (Tokyo). 1994 Mar;47(3):376-9. [2]. H A Whaley. The Structure of Lipoxamycin, a Novel Antifungal Antibiotic. J Am Chem Soc. 1971 Jul 28;93(15):3767-9.
