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  • Maleimido-tri(ethylene glycol)-propionic acid
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Maleimido-tri(ethylene glycol)-propionic acid

Maleimido-tri(ethylene glycol)-propionic acid 是一种可切割的 ADC linker,用于合成抗体-药物偶联物 (ADCs)。Maleimido-tri(ethylene glycol)-propionic acid 用于 neolymphostin 为基础的 ADC 前体的制备,用于位点特异性半胱氨酸突变体曲妥珠单抗- A114C 的偶联。

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¥3262-5400
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2610-4320
Maleimido-tri(ethylene glycol)-propionic acid的二维码

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  • 库存: 现货
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  • 货号: ajcx29484
  • CAS: 518044-40-1
  • 别名: 马来酰亚胺-三聚乙二醇-丙酸,Mal-PEG3-acid
  • 分子式: C13H19NO7
  • 分子量: 301.29
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1].


Mal-PEG3-C2-acid can be used to synthesis linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7[1].ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively[1].ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 195 and 202 nM, respectively[1].ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 286 and 274 nM, respectively[1].


[1]. Zhou D,et al. Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947.

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