MRT00033659

MRT00033659 是一种有效的广谱激酶抑制剂，抑制 CK1 (对 CK1δ:IC50=0.9 &#181M) 和 CHK1 (IC50=0.23 &#181M)。MRT00033659 是一种吡唑并吡啶类似物，可以诱导 p53 途径活化和 E2F-1 不稳定。

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库存: 现货

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5mg

￥1625.00

1300.00

- +
10mg

￥2725.00

2180.00

- +
50mg

￥7012.00

5610.00

- +
100mg

￥10250.00

8200.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx29522
CAS: 1401731-54-1
别名:
分子式: C15H14N4O
分子量: 266.3
纯度: >98%
溶解度: DMSO: 83.33 mg/mL (312.92 mM)
储存: Store at -20°C,unstable in solution, ready to use.
库存: 现货

Background

MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation[1].

MRT00033659 (5-40 µM; 48 hours) is sufficient to significantly reduce cell number of 5 µM[1]. MRT00033659 (1-80 µM; 48 hours) induces substantial cell death from 5 µM[1]. MRT00033659 (0.2-80 µM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2 and p21 proteins, as well as E2F-1 destabilisation from 0.2 µM to 5 µM[1]. MRT00033659 does not inhibit p38α MAPK[1]. Cell Viability Assay[1] Cell Line: A375 cells

[1]. Huart AS, et al. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novelactivator of the p53 pathway. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5578-85.