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- PKD (Protein kinase D)
- O-Desmethyl Midostaurin
O-Desmethyl Midostaurin
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) 是 Midostaurin 的活性代谢物，通过细胞色素 P450 肝酶代谢产生，可以作为 Midostaurin 在体内代谢的指标之一。Midostaurin 是一种多靶点蛋白激酶 (kinase) 抑制剂，IC50 范围为 22-500 nM。
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5mg￥19762.0015810.00- +
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- 货号: ajcx29558
- CAS: 740816-86-8
- 别名: CGP62221; O-Desmethyl PKC412
- 分子式: C34H28N4O4
- 分子量: 556.61
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83.
