A flavonoid with diverse biological activities
Rhamnocitrin is a flavonoid that has been found in C. erythrophyllum and has diverse biological activities.1,2 It is active against S. sonei, S. aureus, and M. luteus when used at concentrations ranging from 25 to 100 ?g/ml.1 Rhamnocitrin scavenges DPPH radicals in a cell-free assay (IC50 = ~25 ?M).2 It also inhibits LPS- and IFN-γ-induced production of nitric oxide (NO), TNF-α, and IL-6 in isolated mouse peritoneal macrophages.
1.Martini, N.D., Katerere, D.R.P., and Eloff, J.N.Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae)J. Ethnopharmacol.93(2-3)207-212(2004) 2.Fang, S.-H., Rao, Y.K., and Tzeng, Y.-M.Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinariaJ. Ethnopharmacol.116(2)333-340(2008)
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