Ribociclib D6
RibociclibD6(LEE011D6)是Ribociclib的一种氘代化合物。Ribociclib是一种高度特异性的CDK4/6抑制剂，IC50值分别为10nM和39nM，对cyclinB/CDK1复合体的活性低于其1000倍。
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包装价格促销价数量
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5mg￥7337.005870.00- +
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10mg￥12287.009830.00- +
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- 货号: ajcx29658
- CAS: 1328934-40-2
- 别名: LEE011-d6
- 分子式: C23H24D6N8O
- 分子量: 440.57
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Ribociclib D6 (LEE011 D6) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].
[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.
