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- Janus kinase (JAK)
- Tofacitinib metabolite-1
Tofacitinib metabolite-1
Tofacitinib metabolite-1 是 Tofacitinib 的代谢物, JAK 抑制剂。Tofacitinib metabolite-1 可用于 Tofacitinib 的药动力学和代谢研究。
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5mg￥5175.004140.00- +
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- 货号: ajcx29740
- CAS: 1640971-51-2
- 别名: 托法替尼杂质
- 分子式: C16H20N6O2
- 分子量: 328.37
- 纯度: ＞98%
- 溶解度:
- 储存: 4°C, protect from light
- 库存: 现货
Background
Tofacitinib metabolite-1 is a metabolite of Tofacitinib , a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib[1][2].
[1]. Martin E Dowty, et al. The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans. Drug Metab Dispos. 2014 Apr;42(4):759-73. [2]. Matthias Gehringer, et al. Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres. ChemMedChem. 2014 Nov;9(11):2516-27.
