(E)-10-Hydroxynortriptyline
An active metabolite of amitriptyline and nortriptyline
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包装价格促销价数量
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5mg￥5937.004750.00- +
- 货号: ajcx29804
- CAS: 47132-16-1
- 别名: E-10-OH-NT
- 分子式: C19H21NO
- 分子量: 279.38
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
trans-10-hydroxy Nortriptyline is an active metabolite of the tricyclic antidepressants amitriptyline and nortriptyline .1,2 It is formed from amitriptyline and nortriptyline by the cytochrome P450 (CYP) isoform CYP2D6.1 trans-10-hydroxy Nortriptyline inhibits norepinephrine reuptake in rat cortical slices and isolated human plasma (EC50s = 160 and 176 nM, respectively).2
1.Coutts, R.T., Bach, M.V., and Baker, G.B.Metabolism of amitriptyline with CYP2D6 expressed in a human cell lineXenobiotica27(1)33-47(1997) 2.Bertilsson, l., Mellstr?m, B., and Sj?qvist, F.Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptylineLife Sci.25(15)1285-1292(1979)
