(E/Z)-E64FC26是E-E64FC26和Z-E64FC26的混合物。E64FC26(E-E64FC26)是蛋白质二硫键异构酶(PDI)家族的一种有效的泛抑制剂，对PDIA1、PDIA3、PDIA4、TXNDC5和PDIA6的IC50分别为1.9、20.9、25.9、16.3和25.4μM。E64FC26显示抗骨髓瘤活性。
(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].
[1]. Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1. [2]. Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022.
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