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(S)-DehydroVenlafaxine是DehydroVenlafaxine的非活性S-对映异构体。DehydroVenlafaxine是Venlafaxine的杂质。Venlafaxine(Wy45030)是有效的5-羟色胺(5-HT)/去甲肾上腺素(NE)再摄取双重抑制剂。
(S)-Dehydro Venlafaxine is an inactive S-enantiomer of Dehydro Venlafaxine. Dehydro Venlafaxine is an impurity of Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor[1][2].
[1]. Mohanarangam Saravanan, et al. Impurity Profile Study of Venlafaxine Hydrochloride, an Antipsychotic Drug Substance. Synthetic Communications. Volume 40, 2010 - Issue 13. [2]. Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.
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