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(S)-Seco-DuocarmycinSA是一种DNA烷化剂(DNAalkylator),可作为抗体药物偶联物的毒素部分(ADCcytotoxin)起作用。
(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates[1].
[1]. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129(35):10858-69.
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