1-Methylxanthine

1-甲基黄嘌呤属于称为黄嘌呤的有机化合物类别。这些是嘌呤衍生物，在嘌呤部分的碳 2 和 6 处有一个酮基共轭。它也是由嘌呤核苷磷酸化酶从黄苷产生的。可增强肿瘤细胞的放射敏感性

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100mg

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Background

1-Methylxanthine is an active metabolite of caffeine .^1,2 It enhances ionizing radiation-induced DNA double-strand break formation in RKO colorectal cancer cells when used at a concentration of 3 mM.¹ 1-Methylxanthine (100 ?M) inhibits the uptake of 6-carboxyfluorescein in CHO cells overexpressing human organic anion transporter 1 (OAT1).² It has also been used as a biomarker of caffeine consumption.³

1.Youn, H., Kook, Y.H., Oh, E.-T., et al.1-Methylxanthine enhances the radiosensitivity of tumor cellsInt. J. Radiat. Biol.85(2)167-174(2009) 2.Rengelshausen, J., Lindenmaier, H., Cihlar, T., et al.Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthineBiochem. Biophys. Res. Commun.320(1)90-94(2004) 3.González-Domínguez, R., Castellano-Escuder, P., Carmona, F., et al.Food and microbiota metabolites associate with cognitive decline in older subjects: A 12-year prospective studyMol. Nutr. Food Res.65(23)e2100606(2021)