7-Octynoicacid(compound42)是一种PROTAClinker。7-Octynoicacid可用于合成一系列PROTAC分子。PROTAC分子含有两个通过linker连接的不同配体;一种是E3泛素连接酶配体，另一种是靶蛋白配体。PROTAC利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17.
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