Acid-PEG3-C2-Boc

Acid-PEG3-C2-Boc是一种PROTAClinker，属于PEG和Alkyl/ether类，可以用于合成降解EGFR和抑制mTOR的PROTAC。

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库存: 现货

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数量
100mg

￥1325.00

1060.00

- +
250mg

￥2425.00

1940.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. [2]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.