A prodrug form of N-desethyl amodiaquine
Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine .1,2 It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.1 Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.3
1.Mariga, S.T., Gil, J.P., Sisowath, C., et al.Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitroAntimicrob. Agents Chemother.48(11)4089-4096(2004) 2.Sá, J.M., Chong, J.L., and Wellems, T.E.Malaria drug resistance: New observations and developmentsEssays Biochem.51137-160(2014) 3.Jacobs, R.L., Alling, D.W., and Cantrell, W.F.An evaluation of antimalarial combinations against Plasmodium berghei in the mouseJ. Parasitol.49(6)920-925(1963)
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