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- AUNP-12 TFA
AUNP-12 TFA
A PL-1/PD-L interaction inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1175.00940.00- +
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5mg￥3050.002440.00- +
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10mg￥4850.003880.00- +
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- 货号: ajcx30206
- CAS: N/A
- 别名: NP-12 TFA
- 分子式: C142H226N40O48.C2HF3O2
- 分子量: 3375.57
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
AUNP-12 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligands, PD-L1 and PD-L2.1 It inhibits binding of soluble PD-1 to HEK293 cells expressing human PD-L2 (EC50 = 0.72 nM). AUNP-12 reverses PD-L1-induced inhibition of proliferation of PMA-stimulated, PD-1-expressing rat peripheral blood mononuclear cells (PBMCs; EC50 = 0.41 nM). It reduces tumor growth and lung metastasis by 44 and greater than 60%, respectively, in a B16/F10 mouse melanoma model when administered at a dose of 5 mg/kg per day.
1.Sasikumar, P.G.N., Ramachandra, M., Vadlamani, S.K., et al.Immunosuppression modulating compounds(2011)
