AZ7550 Mesylate

An active metabolite of AZ 9291

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库存: 现货

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5mg

￥3050.00

2440.00

- +
10mg

￥4750.00

3800.00

- +

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Background

AZ 7550 is an active metabolite of AZ 9291 .¹ It inhibits the insulin-like growth factor 1 receptor (IGF-1R) in a cell-free assay (IC₅₀ = 1.6 ?M). It inhibits EGFR autophosphorylation in H1975 and PC-9 cells expressing the respective constitutively active mutants EGFR^T790M/L858R and EGFR^Exon19del (IC₅₀s = 0.045 and 0.026 ?M, respectively), as well as in LoVo cells expressing wild-type EGFR (IC₅₀ = 0.786 ?M).

1.Finlay, M.R., Anderton, M., Ashton, S., et al.Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptorJ. Med. Chem.57(20)8249-8267(2014)