Benzothiohydrazide是抗结核药物Isoniazid的一种类似物,具有抗结核活性,对M.tuberculosis野生型和临床突变型(IC1和IC2)的MIC分别为132μM和264μM。
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Benzothiohydrazide is an analogue of anti-tubercular agent Isoniazid. Benzothiohydrazide exhibits anti-tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC1 and IC2)[1].
[1]. J. Laborde, et al. Synthesis, oxidation potential and anti-mycobacterial activity of isoniazid and analogues: insights into the molecular isoniazid activation mechanism. ChemistrySelect, 1(2), 172-179.