BLT-1

An SR-BI inhibitor

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库存: 现货

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数量
5mg

￥1212.00

970.00

- +
10mg

￥2175.00

1740.00

- +
50mg

￥5937.00

4750.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx30286
CAS: 321673-30-7
别名: Block lipid transport-1
分子式: C12H23N3S
分子量: 241.4
纯度: >98%
溶解度: DMSO: 41.67 mg/mL (172.62 mM); Water: < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

BLT-1 is an inhibitor of scavenger receptor B1 (SR-BI).¹ It inhibits uptake of [³H]cholesteryl ester-HDL in LDL receptor-deficient CHO cells expressing mouse SR-BI ((ldlA[mSR-BI]) cells; IC₅₀ = 0.11 ?M) and the efflux of cholesterol from ldlA[mSR-BI] cells to HDL (IC₅₀ = 0.15 ?M). BLT-1 (8 ?M) induces developmental defects in zebrafish embryos, an effect that can be prevented by copper chloride.²

1.Nieland, T.J.F., Penman, M., Dori, L., et al.Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BIProc. Natl. Acad. Sci. USA99(24)15422-15427(2002) 2.Raldúa, D., and Babin, P.J.BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish developmentToxicol. Lett.175(1-3)1-7(2007)