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  • BLT-1
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BLT-1

An SR-BI inhibitor

原价
¥1212-5937
价格
970-4750
BLT-1的二维码

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  • 货号: ajcx30286
  • CAS: 321673-30-7
  • 别名: Block lipid transport-1
  • 分子式: C12H23N3S
  • 分子量: 241.4
  • 纯度: >98%
  • 溶解度: DMSO: 41.67 mg/mL (172.62 mM); Water: < 0.1 mg/mL (insoluble)
  • 储存: Store at -20°C
  • 库存: 现货

Background

BLT-1 is an inhibitor of scavenger receptor B1 (SR-BI).1 It inhibits uptake of [3H]cholesteryl ester-HDL in LDL receptor-deficient CHO cells expressing mouse SR-BI ((ldlA[mSR-BI]) cells; IC50 = 0.11 ?M) and the efflux of cholesterol from ldlA[mSR-BI] cells to HDL (IC50 = 0.15 ?M). BLT-1 (8 ?M) induces developmental defects in zebrafish embryos, an effect that can be prevented by copper chloride.2


1.Nieland, T.J.F., Penman, M., Dori, L., et al.Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BIProc. Natl. Acad. Sci. USA99(24)15422-15427(2002) 2.Raldúa, D., and Babin, P.J.BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish developmentToxicol. Lett.175(1-3)1-7(2007)

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