Boc-NH-PEG4-CH2CH2COOH是一种基于PEG的PROTAClinker，用于合成PROTAC。Boc-NH-PEG4-CH2CH2COOH也是一种可降解的ADClinker，用于合成可降解的抗体偶联药物(ADC)的ADClinker。
Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
[1]. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2018114798A1. [2]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1.
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