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- Br-C3-methyl ester
Br-C3-methyl ester
Br-C3-methylester是一种PROTAClinker，属于Alkyl/ether类。可用于合成PROTACPD-1/PD-L1degrader-1。
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500mg￥375.00300.00- +
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- 货号: ajcx30310
- CAS: 4897-84-1
- 别名: 4-溴丁酸甲酯
- 分子式: C5H9BrO2
- 分子量: 181.03
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 [1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Binbin Cheng, et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.
