CH-0793076 TFA
CH-0793076(TP3076)TFA，喜树碱的六环类似物，是TP300的活性药物和主要代谢物。CH-0793076TFA抑制DNA拓扑异构酶I(DNAtopoisomeraseI)，IC50为2.3μM。CH-0793076TFA对表达BCRP(乳腺癌耐药蛋白)的细胞也有活性。
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包装价格促销价数量
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1mg￥9175.007340.00- +
- 货号: ajcx30374
- CAS: N/A
- 别名: TP3076 TFA
- 分子式: C28H27F3N4O6
- 分子量: 572.53
- 纯度: ＞98%
- 溶解度: DMSO: 66.67 mg/mL (116.45 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein)[1].
CH0793076 (TP3076) TFA (6 days at 37°C) shows antiproliferative activity against PC-6/BCRP and PC-6/pRC cells, with IC50s of 0.35 and 0.18 nM, respectively[1].
[1]. Endo M, et al. A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts. Cancer Chemother Pharmacol. 2010 Jan;65(2):363-71.
