Desmorpholinyl Quizartinib-PEG2-COOH|2292116-14-2|安捷凯

Desmorpholinyl Quizartinib-PEG2-COOH

DesmorpholinylQuizartinib-PEG2-COOH包含靶蛋白FLT-3配体和一种基于PEG的PROTACLinker。DesmorpholinylQuizartinib-PEG2-COOH可用于合成PROTACFLT-3degrader1。PROTACFLT-3degrader1是PROTACFLT-3ITD降解剂，IC50为0.6nM。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

Background

Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 . PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM[1].

[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.