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- DOTA-PEG5-azide
DOTA-PEG5-azide
DOTA-PEG5-azide是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
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10mg￥24575.0019660.00- +
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- 货号: ajcx30554
- CAS: N/A
- 别名:
- 分子式: C28H52N8O12
- 分子量: 692.76
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
DOTA-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
