Doxazosin D8

An internal standard for the quantification of doxazosin

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5mg

￥3775.00

3020.00

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Background

Doxazosin-d₈ is intended for use as an internal standard for the quantification of doxazosin by GC- or LC-MS. Doxazosin is a non-selective antagonist of α₁-adrenergic receptors (α₁-ARs; K_is = 3.16, 1, and 3.98 nM for α_1A-, α_1B-, and α_1D-ARs, respectively).¹ It inhibits norepinephrine-induced contractions in isolated rat aortic rings and human prostate strips with pA₂ values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA₂ = 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.

1.Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al.Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studiesBr. J. Pharmacol.118(4)871-878(1996)