An internal standard for the quantification of doxazosin
Doxazosin-d8 is intended for use as an internal standard for the quantification of doxazosin by GC- or LC-MS. Doxazosin is a non-selective antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.16, 1, and 3.98 nM for α1A-, α1B-, and α1D-ARs, respectively).1 It inhibits norepinephrine-induced contractions in isolated rat aortic rings and human prostate strips with pA2 values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2 = 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.
1.Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al.Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studiesBr. J. Pharmacol.118(4)871-878(1996)
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