EBOV/MARV-IN-1
EBOV/MARV-IN-1是一种有效的埃博拉病毒(EBOV)和马尔堡病毒(MARV)抑制剂，在HeLa细胞中具有广谱活性(EC50=0.31和0.82µM)和低细胞毒性(SI>100)。
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包装价格促销价数量
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5mg￥1625.001300.00- +
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10mg￥2725.002180.00- +
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25mg￥4850.003880.00- +
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50mg￥8100.006480.00- +
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100mg￥12825.0010260.00- +
- 货号: ajcx30572
- CAS: 2479465-67-1
- 别名:
- 分子式: C25H30F3N3O2
- 分子量: 461.52
- 纯度: ＞98%
- 溶解度: DMSO: 100 mg/mL (216.68 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells[1].
EBOV/MARV-IN-1 (12.5 µM; 48 h) inhibits HIV/EBOV-GP (EC50=12 nM) and HIV/MARV-GP (EC50=180 nM) pseudotype virus in A549 cells containing a luciferase reporter gene, with low cytotoxicity (SI =2088)[1].
[1]. Gaisina IN, et, al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. J Med Chem. 2020 Jul 9;63(13):7211-7225.
