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- Cyclooxygenase (COX)
- Ketorolac D5
Ketorolac D5
An internal standard for the quantification of ketorolac
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1475.001180.00- +
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5mg￥4900.003920.00- +
- 货号: ajcx30872
- CAS: 1215767-66-0
- 别名: 酮咯酸D5
- 分子式: C15H8D5NO3
- 分子量: 260.3
- 纯度: ＞98%
- 溶解度: Chloroform: slightly soluble,Methanol: slightly soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Ketorolac-d5 is intended for use as an internal standard for the quantification of ketorolac by GC- or LC-MS. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2).1 It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.
1.Zhang, Y., Shaffer, A., Portanova, J., et al.Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 productionJ. Pharmacol. Exp. Ther.283(3)1069-1075(1997)
