LDN-91946
LDN-91946是一种有效的非竞争性的选择性泛素羧基末端水解酶-L1(UCH-L1)抑制剂，Kiapp为2.8μM.
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包装价格促销价数量
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10mg￥550.00440.00- +
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50mg￥1300.001040.00- +
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- 货号: ajcx30900
- CAS: 439946-22-2
- 别名:
- 分子式: C15H10N2O4S
- 分子量: 314.32
- 纯度: ＞98%
- 溶解度: DMSO: 83.33 mg/mL (265.11 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM[1].
LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM[1]. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM[1].
[1]. Mermerian AH, et al. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32.
