A thiol-containing amino acid
L-Homocysteine is a thiol-containing amino acid and an isomer of DL-homocysteine .1 It is formed via demethylation of methionine and acts as a precursor in the biosynthesis of methionine and cysteine.1,2 Hyperhomocysteinemia (HHcy), a disorder characterized by elevated homocysteine levels due to excessive synthesis or decreased degradation of L-homocysteine, is associated with an increased risk of cardiovascular disease and stroke.1,2,3
1.Chrysant, S.G., and Chrysant, G.S.The current status of homocysteine as a risk factor for cardiovascular disease: a mini reviewExpert Rev. Cardiovasc. Ther.16(8)559-565(2018) 2.Moretti, R., and Caruso, P.The controversial role of homocysteine in neurology: From labs to clinical practiceInt. J. Mol. Sci.20(1)231(2019) 3.Perla-kaján, J., and Jakubowski, H.Dysregulation of epigenetic mechanisms of gene expression in the pathologies of hyperhomocysteinemiaInt. J. Mol. Sci.20(13)3140(2019)
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